Treatment of HepG2 with an activator of Akt (sc-79) decreased the loss in cell viability in cells treated with an N-terminal gelsolin1–70 fragment and TRAIL. Treatment of cells with N-terminal gelsolin1–70 fragment and TRAIL in the presence of an Akt activator enhances cell viability at multiple doses of the fragment (1, 2, and 4 μg/ml) after 48 hours incubation by MTT assay (panel A). Western blot analysis exhibited an increase in the phosphorylation of Akt and Erk in sc-79 treated cells (panel B). Densitometric scanning results are shown on the right. Each panel is representative of three independent experiments and mean values ± SD are shown as error bars. Note that cropped gel images are used and the gels were run under the same experimental conditions.