Tumor Survival Curves after aFP Treatment with Anti-CD8 Depletion Antibody. To investigate whether adaptive immunity is necessary to eradicate cancer cells after aFP, tumor inoculation was performed with anti-CD8 depletion antibody to ablate CD8+ T cells in the mouse in the one tumor model. Anti-CD8 depletion antibodies were administered intraperitoneally at a dose of 200 µg per mouse every 3 days from one day before tumor inoculation to removal of mice as endpoint. The graph shows Kaplan-Meier survival curves of mice receiving tumor inoculation and anti-CD8 depletion antibody. The significance values for the difference between the survival curves are: anti-CD8+ aFP vs. aFP: P < 0.005.