Figure 2 | Scientific Reports

Figure 2

From: Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora

Figure 2

Antihyperglycemic effect of mulberry leaf. (a) GTT, both mulberry leaf and glibenclamide could enhance insulin sensitivity of diabetic rat, *P < 0.05 PCG compared with NCG, **P < 0.01 PCG compared with NCG, #P < 0.05 MTG compared with NCG, ##P < 0.01 MTG compared with NCG. (b) Area under curve of GTT, **P < 0.01 compared with NCG. (c) FBG levels of rats, FBG of NCG maintained high level throughout the trial, however, both mulberry leaf and glibenclamide could significantly reduce FBG of diabetic rat, *P < 0.05 PCG compared with NCG, **P < 0.01 PCG compared with NCG, ##P < 0.01 MTG compared with NCG. (d) HbA1c levels of rats, both mulberry leaf and glibenclamide treatments significantly inhibited glycation procedure of diabetic rat, *P < 0.05 compared with NCG. (e) Serum fasting insulin level of rats. (f) HOMA-IR, both mulberry leaf and glibenclamide decreased insulin resistance, *P < 0.05 compared with NCG. (g) HOMA-IS, both mulberry leaf and glibenclamide increased insulin sensitivity, *P < 0.05 compared with NCG. (h) HOMA-β, both mulberry leaf and glibenclamide improved pancreas islet β-cell function, *P < 0.05 compared with NCG. Value = mean ± SD (N = 6).

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