Proteomic analysis of the CPC secretome. (a) CPC secretome inferred from whole label-free (LF) analysis. Distribution of the CPC secretome (465 proteins) by subcellular localization (top) and by enzymatic activity (bottom). (b) Most relevant cytokines (left) and growth factors (right) in the CPC secretome as inferred from whole LF analysis. (c) Comparison of whole LF proteomics secretome and secretome obtained from CPC-conditioned medium (CM); only 19% (104; blue) of the proteins described are common. (d) Distribution of the CPC CM secretome by subcellular localization. (e) The majority of the CPC secretome (>50%) is included in the Exocarta database, indicating association with the exosome compartment.