Nlrp3−/−-HFHC mice showed increased weight gain and hepatic steatosis. Nlrp3−/−-HFHC mice showed increased weight gain (a), despite reduced calories intake/body weight ratio (b) and this was associated with reduced total energy expenditure (TEE) (c). Liver-to-body-weight ratio (d) correlated with hepatic lipid accumulation, evaluated by H&E staining (e) and triglyceride quantification in liver (f). These effects did not correlate with different intestinal lipid absorption (g). Mean ± SE: #p < 0.05 vs Nlrp3−/–-Chow diet; ##p < 0.01 vs Nlrp3−/−-Chow diet; ###p < 0.001 vs Nlrp3−/−-Chow diet; ####p < 0.0001 vs Nlrp3−/−-Chow diet; ç p < 0.05 vs Wt-Chow diet; çç p < 0.01 vs Wt-Chow diet; *p < 0.05; **p < 0.01; ***p < 0.001.