Figure 2 | Scientific Reports

Figure 2

From: Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy

Figure 2

The average number of differentially expressed miRNAs produced by different sets of expression profiles. At the acute stage, the ES model had 26 ± 13 up-regulated and 17 ± 29 down-regulated miRNAs, the pilocarpine model had 32 ± 16 miRNAs up-regulated and 31 ± 33 down-regulated miRNAs, the KA model had 49 ± 67 up-regulated miRNAs and 9 ± 1 down-regulated miRNAs. At the latent stage, the ES model had 11 ± 6 up-regulated miRNAs and 11 ± 8 down-regulated miRNAs, the pilocarpine model had 18 up-regulated miRNAs and 15 down-regulated miRNAs. At the chronic stage, the ES model produced 24 ± 18 up-regulated miRNAs and 8 ± 7 down-regulated miRNAs, the pilocarpine model produced 15 ± 6 up-regulated miRNAs and 12 ± 11 down-regulated miRNAs. The KA model had a pronounced trend toward up-regulated miRNAs rather than down-regulated. The data on differential miRNA expression during the latent stage in the pilocarpine model was provided by a single profile. The standard deviation indicated large variation in the number of differentially expressed miRNAs depending on study, especially for the acute stage.

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