Table 2 Overview of curve characteristics for acetylcholine-induced relaxation in isolated rat aorta’s.

From: Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

  SHR STZ-SHR
Control Vildagliptin Metformin Control Vildagliptin Metformin
PE pre-constriction
 absolute in µm 167 ± 3 155 ± 13 158 ± 9 163 ± 12 152 ± 12 213 ± 21
 % high K+ 89.1 ± 5.6 75.6 ± 6.0 84.8 ± 5.2 81.9 ± 8.0 87.4 ± 12.6 87.3 ± 10.1
ACh-induced relaxation
 EC50-value (log M) −6.67 ± 0.24 −7.46 ± 0.21# −7.53 ± 0.11# −6.82 ± 0.05 −7.03 ± 0.14 −7.02 ± 0.06
 constriction remaining at maximal relaxation (% PE) 71.5 ± 4.6 47.1 ± 6.7# 45.9 ± 5.8# 61.3 ± 4.1 50.7 ± 8.7 42.2 ± 6.5
 Upstroke after maximal relaxation (∆ % PE) 6.2 ± 3.8 4.4 ± 6.2 9.9 ± 15.0 19.6 ± 4.4* 32.7 ± 22.6 14.6 ± 3.3
 AUC (arbitrary units) 170 ± 19 313 ± 21# 264 ± 18# 192 ± 18 217 ± 24 262 ± 28#
  1. Data are mean ± SEM and correspond to the data in Fig. 2. *p < 0.05 STZ-SHR vs. control SHR; #p < 0.05 treatment vs. appropriate control.