Figure 2 | Scientific Reports

Figure 2

From: ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain

Figure 2

Myo19 selectively localizes to a subset of filopodia. U2OS cells were co-transfected with ruby tagged Myo19 and either GFP tagged Myo10 or GFP tagged mDia2ΔDAD (constitutively active form of the formin mDia2) that induce filopodia formation. Both Myo10 and mDia2ΔDAD expressing cells exhibit multiple filopodia, however Myo19 localized only to mDia2ΔDAD induced filopodia tips. Blue – nuclei, green – Myo10 or mDia2ΔDAD, red – ruby tagged Myo19, Magenta – phalloidin stained actin. Bar is 10 µm.