Figure 6 | Scientific Reports

Figure 6

From: HMGB1/Advanced Glycation End Products (RAGE) does not aggravate inflammation but promote endogenous neural stem cells differentiation in spinal cord injury

Figure 6

HMGB1 does not increase cytokines of TNF-α and IL-1β, but RAGE blockade reduced cytokines aroused by LPS in primary spinal neuron culture via ELISA. (a) Quantitative analysis of cytokines of TNF-α at 12 hours in the following groups: ctrl; LPS; HMGB1; LPS + anti-rage; and HMGB1 + anti-rage; (b) Quantitative analysis of cytokines of IL-1β in different groups. Values are means ± SD. &&P < 0.01, &&&P < 0.001 HMGB1 group vs ctrl group, ^^P < 0.01, ^^^p < 0.001LPS + anti-RAGE group vs LPS group.