Figure 5 | Scientific Reports

Figure 5

From: Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice

Figure 5

Circadian rhythm for Pigr gene abundance in submandibular glands in intact SCN-lesioned and Clock −/− mice. (a) Relative mRNA abundance rhythms of Pigr (n = 4) in the submandibular gland. (b) The relative mRNA abundance of Pigr in SCN-lesioned mice compared to that in sham-operated mice at ZT6 and ZT18 (n = 6–7). (c,d) The relative mRNA abundance of Per2 (c) and Pigr (d) in Clock −/− mice compared to that in wild-type (WT) mice at ZT6 and ZT18 (n = 4 for each group). Values are shown as means ± SEM. (a) *p < 0.05, ZT1, ZT5 vs. ZT13 (Kruskal-Wallis test with Dunn post-hoc test), (bd) *p < 0.05, ZT6 vs. ZT18 or WT vs. Clock −/− (Mann-Whitney test).