Table 1 Metabolic pathways involved in MSC-mediated conditioning based on the high-throughput RNA sequencing (WEB-based Gene Set AnaLysis Toolkit).

From: Administration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats

Pathway name Number of genes in the category Number of reference genes in the category Adjusted p-value
Downregulated pathways
 Adipogenesis 10 129 5 × 10−7
 Insulin signaling 9 158 1.36−5
 Fatty acid biosynthesis 5 28 1.36−5
 IL-6 signaling pathway 7 114 0.0001
 B cell receptor signaling pathway 8 199 0.0003
 ErbB signaling pathway 5 60 0.0003
 IL-3 signaling pathway 6 110 0.0004
 EGFR1 signaling pathway 8 213 0.0004
 MAPK signaling pathway 7 165 0.0004
Upregulated pathways
 Nuclear receptors in lipid metabolism and toxicity 4 39 0.0001
 Proteasome degradation 2 59 0.0480
 Translation Factors 2 47 0.035