Figure 3 | Scientific Reports

Figure 3

From: Whole transcriptome profiling of taste bud cells

Figure 3

Upstream regulator effect analysis of chemotaxis and cell migration pathways using Ingenuity Pathway Analysis. Pathways that are known to influence movement of blood and tumour cells are down regulated in type III cells relative to Tas1r3+ cells; these functions likely influence movement of Tas1r3+ taste cells. The top tier in each network shows master regulators, the middle tiers show the intermediate regulators in the data set through which the master regulators exert their effect on the regulated functions, which are shown in the bottom tier. The predicted state of the regulators and affected functions are colour coded, with orange colour indicating activation and blue indicating inhibition. Up-regulated molecules in the middle tiers are colour coded red and down-regulated molecules in green, with the intensity matching the false discovery rate calculated by DESeq. 2. The shape of each molecule indicates its molecular function. The causal relationships that are consistent with Ingenuity Pathway Analysis database are represented with orange and blue lines, while the inconsistent relationships are indicated with yellow lines.

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