New strategies designed to combat fractional killing. (A) Time series simulations with a population of cells treated with cisplatin, a CIAP inhibitor, and a BCL inhibitor. (B) Inhibition of BCL expands the area corresponding to apoptosis; while inhibition of CIAP keeps the time dependent trajectories of the cells at the bottom of the plane. (C) The black solid curve and the red solid curve indicate the BAXm activation threshold before and after Caspase8 activation, respectively. The area at the right of the BAXm activation threshold curve defines the apoptosis area. Hence, the activation of Caspase8 expands the area of apoptosis. (D) Time series simulations with a population of cells treated with cisplatin and a Caspase8 activator.