Figure 1 | Scientific Reports

Figure 1

From: A dynamical framework for complex fractional killing

Figure 1

The molecular interactions in the current representative model. Nodes of different shapes represent the model components; arrows indicate activation; lines and curves with solid circle heads indicate repression. The model consists of three functional modules: p53 signaling, cisplatin signaling, and the control of BAX activation. In the p53 signaling module, p53 is controlled by one positive feedback and one Mdm2 mediated negative feedback. In the module of cisplatin signaling, cisplatin activates an incoherent feedforward loop. In one branch, cisplatin activates p53 to promote apoptosis; in the other branch, cisplatin activates CIAP to inhibit Caspase8, thus inhibiting apoptosis. In the BAX activation module, BH3 promotes the transformation of BAX from the inactive, cytoplasmic form, to the activated mitochondrial form. BAXm is inactivated from the BAXm monomer as well as the BAXm:BCL dimer.

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