Table 3 Prevalence of MTHFR c. 677C > T T and MTHFR c. 1298A > C C allele in the pSS non-MALT patients, pSS patients and healthy control group.

From: MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome

SNPs MTHFR Allele HAPMAP Database (%) pSS non-MALT (n = 19) (%) pSS (n = 262) (%) Healthy controls (n = 600) (%) OR 1 [95% CI] p-value 1 OR 2 [95% CI] p-value 2
c. 677C > T C 69.0 47.4 61.6 63.4 1.79 [0.92–3.46] 0.08 1.93 [1.01–3.68] 0.04
T 31.0 52.6 38.4 36.6
c. 1298A > C A 65.9 89.5 71.0 67.7 0.29 [0.10–0.83] 0.01 0.25 [0.09–0.70] 0.004
C 34.1 10.5 29.0 32.3
  1. Allele analysis was performed with Shesis software (statistically significant if p < 0.05).
  2. OR 1, p-value 1: pSS non-MALT vs pSS, OR 2, p-value 2: pSS non-MALT vs Healthy Controls.
  3. MTHFR: methylene tetrahydrofolate reductase, pSS: primary Sjogren’s syndrome. MALT: mucosa-associated lymphoid tissue, SNP: single nucleotide polymorphisms, OR: odds ratio, HAPMAP: haplotype map, vs: versus.