Table 1 Prevalence of MTHFR genotypes in pSS non-MALT and pSS patients, adjusted by gender and age.

From: MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome

SNPs MTHFR Genotype HAPMAP Database (%) pSS non-MALT (n = 19) n (%) pSS (n=262) n (%) OR codominant model [95%CI] p-value OR dominant model [95%CI] p-value OR recessive model [95%CI] p-value OR overdominant model [95%CI] p-value OR log-additive model [95%CI] p-value
      CC vs CT vs TT   (CT-TT) vs CC   TT vs (CC–CT)   CT vs (CC–TT)    
  CC 46.9 4 (21.1) 102 (38.9) 1.00 0.10 2.70 [0.86-8.43] 0.07 2.74 [0.88-8.51] 0.10 1.29 [0.50-3.31] 0.60 2.13 [1.06-4.30] 0.03
c. 677C>T CT 44.2 10 (52.6) 119 (45.4) 2.26 [0.68-7.48]
  TT 8.8 5 (26.3) 41 (15.7) 4.55 [1.10-18.78]
      AA vs AC vs CC   (AC-CC) vs AA   CC vs (AA-AC)   AC vs (AA-CC)    
  AA 43.4 15 (79.0) 137 (52.3) 1.00 0.03 0.29 [0.09-0.90] 0.02 0.00 [0.00-NA] 0.049 0.44 [0.14-1.37] 0.13 0.31 [0.11-0.88] 0.01
c. 1298A>C AC 45.1 4 (21.1) 98 (37.4) 0.37 [0.12-1.15]
  CC 11.5 0 (0.0) 27 (10.3) 0.00 [0.00-NA]