Figure 1 | Scientific Reports

Figure 1

From: MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome

Figure 1

Long interspersed nuclear element 1 (LINE-1) promoter methylation according to MTHFR genotypes and intrinsic DNA damage levels in pSS patients according to MTHFR genotypes. Panel A: Significantly lower DNA methylation levels among individuals bearing the MTHFR c. 677C > T TT genotype, compared to the CC carriers were observed (TT vs CC: 71.57 ± 5.43 vs 75.56 ± 4.13, p = 0.045). Panel B: No statistically significant differences in DNA methylation levels of LINE-1 promoter were observed among c. 1298A > C CC, AC and AA genotype groups (CC vs AC vs AA: 73.70 ± 5.00 vs 75.42 ± 4.89 vs 73.41 ± 4.98, all comparisons non significant). Panel C: No statistically significant differences in DNA double-strand break levels (expressed as Olive Tail Moments, arbitrary units) between MTHFR c. 677C > T genotypes (CC vs CT vs TT: 11.67 ± 5.40 vs 11.23 ± 5.53 vs 15.74 ± 6.30). Panel D: Decreased levels of comet assay units among pSS patients carrying the MTHFR c. 1298A > C AC genotype compared to those bearing the c. 1298A > C AA genotype (AA vs AC: 14.41 ± 4.38 vs 7.89 ± 5.54, p = 0.04). MTHFR: methylene tetrahydrofolate reductase, pSS: primary Sjogren’s syndrome.