Figure 6 | Scientific Reports

Figure 6

From: The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket

Figure 6

Specific ligand substitutions decrease the EC50 values for TAS2R16 activation. Comparative dose-response studies were performed with wild-type TAS2R16 and the W261A variant for ligand pairs (a) 4-NP-β-mannoside and 4-NP-β-glucoside, differing in the orientation of the 2′-OH group, (b) 4-NP-β-glucoside and phenyl-β-glucoside, and (c) salicin and phenyl-β-glucoside. Error bars represent the standard deviation, n = 4–8 replicate points.