Figure 4 | Scientific Reports

Figure 4

From: The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket

Figure 4

TAS2R16 residues that define ligand specificity. (a–d) Diagrams of TAS2R16 showing the locations of residues where mutations gave high activation with at least one ligand, low activation with another ligand, and >2.5-fold differential response among ligands. Each panel shows residues (in blue) where a mutation resulted in decreased activation by the specific ligand.

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