Table 1 Expression changes upon coffee/xenobiotics exposure of initial set of genes selected based on existing literature.

From: Use of Microarray Datasets to generate Caco-2-dedicated Networks and to identify Reporter Genes of Specific Pathway Activity

Gene Name Pathway Reference Significant change in expression (Fold Change larger/smaller than ±1.5)
SQSTM1 Nrf2 Jain et al., 201068 Yes
HMOX1 Nrf2 Bøhn et al., 201433 Yes
Nrf2 Nrf2 Bøhn et al., 201433 No
ABCC1 Nrf2 Adachi et al., 200769 No
ABCC2 Nrf2 Adachi et al., 200769 No
NQO1 Nrf2 Bøhn et al., 201433 Yes
ABCG2 Nrf2 Isshiki et al., 201170 No *
GSTP1 Nrf2 Steinkellner et al., 200571 Yes
ARNT AhR Ishikawa et al., 2014; Yeager et al., 200932, 72 No
AhR AhR Kalthoff et al., 201073 Yes
CYP1A1 AhR Ishikawa et al., 201432 Yes
TiPARP AhR Diani-Moore et al., 201074 Yes
UGT1A6 AhR Yeager et al., 200972 Yes
CYP1A2 AhR Ishikawa et al., 201432 Not detected
CYP1B1 AhR Ishikawa et al., 201432 Not detected
AHRR AhR Mimura et al., 2003; Abel et al., 201030, 31 Not detected
  1. ‘*’Indicates genes found to be significantly differentially expressed (Fold change >±1.5) in Turkish Coffee only. Genes were considered to be responsive if they were expressed in at least two coffee samples.