Exosomes from colostrum are enriched with proteins implicated in immune response. (a) Venn diagram of proteins identified in MM and colostrum exosomes. More than 4980 proteins were uniquely identified in colostrum samples. (b) Functional enrichment analysis using FunRich revealed various proteins associated with innate immune response, inflammatory response, acute-phase response, platelet activation, and cell growth were highly enriched in exosomes isolated from colostrum (24, 48 and 72 h sample) along with significant enrichment in 24 h sample on its own. * Denotes P < 0.05. (c) Histogram representing proteins related to complement activation and antimicrobial peptides were significantly enriched in exosomes from colostrum and 24 h sample when compared with MM. * Denotes P < 0.05.