Figure 6 | Scientific Reports

Figure 6

From: Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence

Figure 6

Effects of compound #G43 on commensal single and dual species biofilms. (A) S. mutans, S. gordonii, and S. sanguinis were treated with DMSO or 25 µM of compound #G43, and the biomasses of each treated biofilm were quantitated by crystal violet staining and measured at OD562. (B) The cell viability of dual species biofilms was determined by the numbers of CFU in a logarithmic scale using S. mutans, and S. sanguinis. (C) The cell viability of dual species biofilms was determined by the numbers of CFU in a logarithmic scale using S. mutans, and S. gordonii. (D) Species distribution in dual species biofilms with S. mutans and S. sanguinius. Bars represent the mean and standard deviations of three independent experiments. (E) Species distribution in dual species biofilms with S. mutans and S. gordonii. Bars represent the mean and standard deviations of three independent experiments. *P < 0.05.

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