Table 1 Details of predicted in silico ADMET risk range and risk parameters of compound P-902 and standard anticancer drug topotecan.

From: 3D-QSAR studies on Maslinic acid analogs for Anticancer activity against Breast Cancer cell line MCF-7

Risk Absorption P450 oxidation Mutagenicity Toxicity ADMET Risk Risk Parameters
Range 0–8 0–6 0–4 0–7 0–24  
P-902 3.26 0.0 0.0 0.96 4.22 Size, charge, water solubility, lipophilicity
Topotecan (control) 0.0 0.0 2.0 2.0 2.0 Hepatotoxicity, inhibition of 3A4 oxidation of midazolam