Figure 2 | Scientific Reports

Figure 2

From: Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells

Figure 2

Comparison of differential expression and TB susceptibility GWAS results. (a,b) The y-axis is the fold enrichment of SNPs with p-value less than 0.05 from the (a) GWAS of TB susceptibility in Russia18 or (b) height in individuals of European descent25. The x-axis is bins of genes with increasingly stringent effect size cutoffs of the absolute expression log fold change between putatively susceptible and resistant individuals in the non-infected state. The effect size cutoffs were chosen such that each bin from left to right contained approximately 25 fewer genes. The red line shows the results from the actual data. The grey lines are the results from 100 permutations. The dashed blue line at y = 1 represents the null expectation. (cf) Boxplots of the area under the curve of the fold enrichment (red line in (a,b)) minus the background level (blue y = 1 line in (a,b)) for each of the 5 GWAS13, 18, 19 considered for the 4 differential expression contrasts: (c) resistant vs. susceptible individuals in the non-infected state, (d) resistant vs. susceptible individuals in the infected state, (e) effect of treatment in resistant individuals, (f) effect of treatment in susceptible individuals. The boxplot is the result of the 100 permutations, and the red point is the result from the actual data. As a reference, the leftmost boxplot in (c) corresponds to the enrichment plot in (a), and the rightmost boxplot in (c) corresponds to the enrichment plot in (b).