Clinical imaging and morphological features of the tumors (biopsies) of Patient 1. Two low-signal-intensity areas in the left temporal and occipital lobes and the ring-like peripheral edema are shown in non-enhanced (A) and corresponding enhanced T1-weighted MRI images (B). The lesions and edema are indicated by arrows. Calcification (indicated by arrows) was apparent in the occipital lesion under non-enhanced CT (C and D). (E) The sites of ten biopsies harvested from the surgical resection specimen are represented schematically on the MRI image. (F–O) Histologic specimens of the ten tumor samples stained with H&E.