Figure 2 | Scientific Reports

Figure 2

From: Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress

Figure 2

Stress and social isolation exacerbate stress response in ancestrally stressed rats. Shown are plasma corticosterone levels two days before stress (Pre-stress), the first day of stress (Post-stress1), and the last day of stress (Post-stress2). (A) Plasma CORT significantly rose in MS + S-SI rats in response to stress exposure only in the chronic phase. (BD) Comparison of changes in CORT levels influenced by maternal multigenerational stress and the double-hit protocol at different time points. Asterisks indicate significant differences: *p ≤ 0.05, **p ≤ 0.01; ANOVA. Error bars show ± SEM.