Figure 5 | Scientific Reports

Figure 5

From: Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development

Figure 5

CXCR4 cKO Thymocytes Compete Effectively With WT Counterparts During T-cell Development. (a) Experimental schematic for the generation of competitive bone marrow chimeras. (b) FACS analysis of T-cell development within each donor population for CD4Cre and CXCR4 cKO chimeras. (c) Ratio of CD45.2+/CD45.1+CD45.2+ cells in each type of chimera for the indicated populations of thymocytes. Data is normalised to chimerism at the ETP stage of development. Quantitation is generated from three independent experiments where n > 12, unpaired Student’s t test shows no significant difference. Error bars represent SEM.