PGE2, 6-keto-PGF1α and LTC4 peritoneal levels in male and female mice after zymosan-induced peritonitis. Mice were treated with zymosan (i.p.), sacrificed at the indicated time points and (A) PGE2 and (C) LTC4 were measured in peritoneal exudates from male and female mice, and (B) 6-keto-PGF1α was measured in peritoneal exudates 4 hrs after zymosan injection. Time zero (T0) corresponded to untreated mice. Values represent means ± S.E.M; n = 10 mice/T0; n = 10 mice/2 hrs; n = 10 mice/4 hrs; n = 6 mice/8 hrs. ###p < 0.001 and #p < 0.05, male vs female mice; two-way ANOVA plus Bonferroni (A and C) and two-tailed Student’s t test (B).