Figure 5 | Scientific Reports

Figure 5

From: Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

Figure 5

FAK and myosin-II activities are required for durotaxis in PSCs. (a) Average cell migration distance at the rigidity boundary over a 12-hour period for control PSCs, PSCs transfected with siRNA for FAK, and PSCs treated with blebbistatin. Positive values indicate movement towards higher rigidity, values close to 0 indicate random, undirected movement. Histogram bars represent mean ± SEM. ***p < 0.001. (b) Representative images of PSC migration over a 5 h period. Scale bar 25 μm.