Effect of SLAB51 on proteasomal substrates. Detection of the levels of ubiquitinated proteins (panel A), p27 (panel B) and p53 (panel C) in SLAB51 treated and untreated wt and AD mice. The densitometric analyses obtained from five separate blots and representative immunoblots are shown. Equal protein loading was verified by using an anti-GAPDH antibody. The detection was executed by an ECL western blotting analysis system. Data points marked with an asterisk are statistically significant compared to 8-week-old control mice (*p < 0.05). Data points marked with a hash are statistically significant compared to their respective control mice at the same time point (#p < 0.05). Uncropped gels are reported in Supplemental Figure 1.