Figure 2 | Scientific Reports

Figure 2

From: Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Figure 2

Microbiota analysis. PCoA plots based on unweighted Unifrac distances and rarefaction curves are presented. The microbiota was analyzed using 16S rRNA gene sequencing. PCoA plots based on unweighted Unifrac distances reveal separation between the microbiota of wt and AD mice at all time points, indicating that the affected mice have different microbiota structure compared to wt mice. No significant differences were found in alpha diversity indices, revealing no difference in species richness. The progression over time from week 8 to week 24 was more pronounced in the AD mice compared to the wt mice. Also, treatment with SLAB51 induced larger changes in AD mice compared to wt mice, but no differences in species richness (t0 = 8 weeks; t1 = 12 weeks; t2 = 18 weeks; t3 = 24 weeks).