Table 2 Meropenem susceptibilities (mg/L) for 48 Klebsiella isolates from diverse locations and with diverse resistance mechanisms.

From: Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae

Isolate Origin Mechanism Referring Lab’s MIC MICBMD MICFAST BMD S/NS FAST S/NS
2440606 England   ≤0.06 ≤0.25 ≤0.25 S S
2880622 England   ≤0.06 ≤0.25 ≤0.25 S S
51575 Sweden ESBL 0.064 ≤0.25 ≤0.25 S S
515870 Sweden ESBL 0.125 ≤0.25 ≤0.25 S S
ATCC 700603 USA   ≤0.25 ≤0.25 ≤0.25 S S
ATCC BAA 1706 USA   ≤0.25 ≤0.25 ≤0.25 S S
3354 Australia   ≤0.25 ≤0.25 0.5 S S
18397 Australia   ≤0.25 ≤0.25 ≤0.25 S S
43288 Australia   ≤0.25 ≤0.25 ≤0.25 S S
43292 Australia   ≤0.25 ≤0.25 ≤0.25 S S
43358 Australia   ≤0.25 ≤0.25 ≤0.25 S S
43854 Australia   ≤0.25 ≤0.25 ≤0.25 S S
A1 Norway   S ≤0.25 ≤0.25 S S
A2 Norway   S ≤0.25 ≤0.25 S S
A3 Norway   S ≤0.25 ≤0.25 S S
A4 Norway   S ≤0.25 ≤0.25 S S
A7 Norway   S ≤0.25 ≤0.25 S S
A13 Norway   S ≤0.25 ≤0.25 S S
A15 Norway   S ≤0.25 ≤0.25 S S
A16 Norway   S ≤0.25 ≤0.25 S S
2890369 England   1 ≤0.25 0.5 S S
2980639 England   1 ≤0.25 0.5 S S
10924 Sweden KPC 4 ≤0.25 0.5 S S
3040820 England pAmpC ≤0.06 0.5 ≤0.25 S S
270902 England   0.125 0.5 ≤0.25 S S
44271 Australia   ≤0.25 0.5 0.5 S S
K23 Australia IMP - 4 0.5 2 0.5 S S
500638 Sweden pAmpC ≤0.25 4 2 NS NS
KS1 Sri Lanka OXA-181 1 4 2 NS S
374 Sweden VIM >32 8 32 NS NS
K16 Australia IMP - 4 2 16 2 NS S
ATCC BAA 1705 USA KPC 8 16 8 NS NS
200822 Sweden KPC 8 16 8 NS NS
A20 Norway NDM-1 R 16 16 NS NS
70708 Sweden KPC 16 32 32 NS NS
71076 Sweden KPC ≥32 32 32 NS NS
3000770 England NDM-1 >32 32 8 NS NS
N17 Sweden NDM-1 ≥32 32 32 NS NS
K2 Australia OXA-181 64 32 32 NS NS
2880654 England KPC 4 64 32 NS NS
194 Sweden VIM ≥32 64 16 NS NS
KS17 Sri Lanka OXA-181 ≥32 64 64 NS NS
K1 Australia OXA-181 64 64 32 NS NS
KS2 Sri Lanka OXA-181 ≥32 128 16 NS NS
KS23 Sri Lanka OXA-181 ≥32 128 64 NS NS
3080800 England KPC >32 256 32 NS NS
K8 Australia NDM-1 >256 >256 >256 NS NS
K14 Australia KPC 256 >256 >256 NS NS
  1. MICFAST: FAST method MIC.
  2. MICBMD: broth microdilution MIC.
  3. S: Susceptible to meropenem, MIC ≤ 2 mg/L.
  4. NS: Non-susceptible to meropenem, MIC > 2 mg/L.
  5. 48 isolates were exposed to therapeutic grade meropenem and subjected to FAST in technical triplicate, with the MICFAST and MICBMD values reported as the mode of replicates. Interpretation was according to EUCAST criteria: (S = MIC ≤2 mg/L; NS = MIC >2 mg/L).