Figure 1: Scientific Reports

Figure 1

From: Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis

Figure 1
Figure 1

A molecular system model for IPF. It involves four crucial biological pathways (Hedgehog signaling, Wnt signaling, TGFβ signaling and Cytokine-chemokine signaling) having cross-talk with each other. The model describes the mechanism and several regulatory components involved in IPF disease mechanism causing increased cell proliferation, adhesion, reduced differentiation, altered apoptosis and epithelial to mesenchymal transition. DEGs Frizzled 5 receptor, LTBP1, HHIP, BOC, CXCL12, CXCL14, ARRB1, NBL1 and SOCS3 appeared critical in IPF.