Figure 2 | Scientific Reports

Figure 2

From: Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

Figure 2

Binding of TGF-β1 to immobilized TβR-II and TβR-I after pre-incubation with tetrameric GAG derivatives. (A) Relative binding of 40 nM TGF-β1 to TβR-II alone and after pre-incubation with 0.1, 2, 20 and 200 µM D.U. of HA dp4 and psHA dp4. (B) Relative binding of 120 nM TGF-β1 to TβR-I alone and after pre-incubation with 0.1, 2, 20 and 200 µM D.U. of HA dp4 and psHA dp4. Values represent the mean ± SD of n = 3. Two-way ANOVA: *p < 0.05; ***p < 0.001 vs. respective treatment; #p < 0.05; ###p < 0.001 vs. TGF-β1 only.

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