Figure 2 | Scientific Reports

Figure 2

From: Common sequence variants affect molecular function more than rare variants?

Figure 2

Higher SNAP2-scores imply stronger effect upon molecular function. We classified SAVs from the Protein Mutant Database (PMD) according to their impact upon molecular protein function into three classes (mild, moderate, and severe). Here, we repeat this analysis applying SNAP2 to the subset of human SAVs in PMD. We show density distributions, instead of cumulative. Although the three curves overlap, the shift is significant and consistent (black curve with most effect highest shift to right, orange curve with weakest shift most to the left). Thus, the SNAP2-score correlated with the strength of the effect upon molecular function.

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