Membrane interaction and internalization of MAG-ARA. (a) Initial configuration of the MAR-ARA NP in vacuum. Fe is shown in yellow, oxygen in red, carbon in cyan in van der Waals representation. (b) Final configuration of the MAR-ARA NP in contact with a DPPC bilayer. Fe is shown in yellow, oxygen in red, carbon in cyan in van der Waals representation. (c) Example of L-arabinose and D-galactose hydrogen bonds as they interact with the phosphate group of DPPC. Hydrogen atoms have been omitted for clarity. Oxygen is shown in red, carbon in cyan in licorice representation. (d) Superposition of a confocal fluorescence image (blue) and a bright filed image from MDA-MB-231 breast cancer cells incubated with MAG-ARA and control (MAG-PEG/Amine) NPs.