Table 1 List of representative dysregulated genes between APFL and AP.

From: RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study

Gene name Description Log2 (Fold change) Functions Significance (P-value)
Log2 (APFL/AP)
RT1-A3 Uncharacterized protein 18.07504 Positive regulation of T cell mediated cytotoxicity Yes (1.32E-05)
MSC Musculin 12.34538 Negative regulation of transcription from RNA polymerase II promoter Yes (9.45E-04)
FBXO27 F-box protein 27 11.24744 Glycoprotein binding Yes (1.76E-07)
MSX1 Msh homeobox 1 10.72489 Negative regulation of cell growth Yes (3.39E-04)
RGD1561212 Similar to RIKEN cDNA 10.69475 Exhibits retinoic acid receptor binding Yes (1.46E-07)
SIGLEC8 Sialic acid binding Ig-like lectin 8 9.65489 Intracellular signal transduction Yes (2.15E-05)
RAMP3 Receptor (G protein-coupled) activity modifying protein 3 9.49772 Regulation of G-protein coupled receptor protein signaling pathway Yes (3.41E-18)
ZFYVE28 Zinc finger, FYVE domain containing 28 9.45763 Negative regulation of epidermal growth factor Yes (7.88E-09)
TNFAIP6 Tumor necrosis factor alpha induced protein 6 9.33946 Negative regulation of inflammatory response Yes (1.36E-06)
AOC1 Amine oxidase, copper containing 1 9.18586 Amine metabolic process Yes (1.03E-04)
TNN Tenascin N 8.82202 Cell-matrix adhesion Yes (4.54E-07)
PTX3 Pentraxin 3 8.80702 Innate immune response Yes (1.73E-06)
LMX1A LIM homeobox transcription factor 1 alpha 8.36729 Regulation of transcription, DNA-templated Yes (1.65E-04)
RASEF RAS and EF hand domain containing 7.90165 Rab protein signal transduction Yes (1.77E-04)
LOC497963 Similar to Nitric oxide synthase 7.78913 Nitric oxide biosynthetic process Yes (2.15E-03)
DGKH Diacylglycerol kinase 7.55722 Protein oligomerization Yes (4.43E-06)
SLC7AL1 Solute carrier family 7, member 11 7.18928 Response to oxidative stress Yes (7.32E-06)
DNM3 Dynamin 3 5.22016 Anatomical structure development Yes (1.46E-07)
LRRC8E Leucine rich repeat containing 8 family 5.07676 Ion transport Yes (2.36E-06)
VWA2 Von Willebrand factor A domain containing 2 4.13783 Regulation of insulin receptor signaling pathway Yes (2.53 E-03)
EGR2 Early growth response 2 4.11453 Cellular protein modification process Yes (5.49 E-06)
FOSL2 Fos-like antigen 2 4.03226 Positive regulation of fibroblast proliferation Yes (1.49 E-03)
TREM1 Triggering receptor expressed on myeloid cells 1 3.94884 Neutrophil chemotaxis Yes (3.92 E-03)
FOSL1 Fos-like antigen 1 3.30191 Neurological system process Yes (1.80 E-05)
GAS1 Growth arrest-specific 1 2.79755 Negative regulation of mitotic cell cycle Yes (1.10E-20)
WDR4 WD repeat domain 4 1.30914 tRNA methylation Yes (8.61E-03)
PTPRM Protein tyrosine phosphatase, receptor type, M −1.0036 Peptidyl-tyrosine dephosphorylation Yes (1.55 E-04)
CDKN1C CDKI protein long isoform −1.71620 Cell cycle arrest Yes (6.87 E-03)
UBD Ubiquitin D −2.32347 Protein ubiquitination Yes (2.83E-06)
RGMA Repulsive guidance molecule family member A −2.87523 Negative regulation of collateral sprouting Yes (8.81E-19)
BRDT Bromodomain, testis-specific −2.90388 Chromatin remodeling Yes (4.13 E-03)
CD8A CD8a molecule −3.37913 Response to stress Yes (6.91E-06)
FOXH1 Forkhead box H1 −3.95036 Anatomical structure development Yes (9.49E-23)
PDE3A Phosphodiesterase 3A −4.67631 Small molecule metabolic process Yes (4.37E-06)
TFF3 Tff3 molecule −4.82677 Regulation of glucose metabolic process Yes (5.44E-04)
OTOGL Otogelin-like −6.85145 Sensory perception of sound Yes (6.46 E-04)
NPR3 Natriuretic peptide receptor 3 −8.79741 Negative regulation of adenylate cyclase activity Yes (1.81E-03)
LOC100360055 Cytochrome P450 2B15-like −9.82802 Xenobiotic metabolic process Yes (8.93E-05)
MMD2 Monocyte to macrophage differentiation -associated 2 −10.26003 Protein phosphorylation Yes (2.30E-08)
CML3 Camello-like 3 −10.90368 Gastrulation with mouth forming second Yes (1.13E-13)
ALDH1A7 Aldehyde dehydrogenase family 1 −13.13943 Oxidation-reduction process Yes (3.74E-28)