Fig. 2 | Scientific Data

Fig. 2

From: Multi omics analysis of fibrotic kidneys in two mouse models

Fig. 2

Principal component analysis (PCA) of all UUO datasets and FA proteins. The normalized expression abundance of mRNAs, proteins and miRNA was used. Each color represents a time point in the dataset. (a) miRNA expression in kidneys from the UUO model shows day 3 and 7 being in the same cluster, while the normal and the latest time points are distinct. (b) The greatest variation in gene expression in the UUO model is observed along the first principal component (PC) between normal and injured samples, with the second PC separating injury times. (c) A similar pattern is observed using UUO protein expression, with higher consistency within sample groups allowing for better discrimination between time points. (d) Protein expression in the FA model shows different clusters for each time point, PC1 separating normal from the injured samples, and PC2 separating early injury from later time points.

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