Fig. 1: COVIDep provides an up-to-date set of B-cell and T-cell epitopes that can serve as potential vaccine targets for SARS-CoV-2. | Nature Protocols

Fig. 1: COVIDep provides an up-to-date set of B-cell and T-cell epitopes that can serve as potential vaccine targets for SARS-CoV-2.

From: COVIDep: a web-based platform for real-time reporting of vaccine target recommendations for SARS-CoV-2

Fig. 1

a, The identified epitopes are experimentally derived from SARS-CoV and have a close genetic match with the available SARS-CoV-2 sequences (see Supplementary Figure 1 for a detailed protocol description). b, An example of the T-cell epitopes reported by COVIDep (as of 20 May 2020) for the spike protein of SARS-CoV-2. Here, the Search box (in the top right) was used to select only the HLA-A*02:01-restricted epitopes. (An explanation of all interactive COVIDep visualizations is incorporated in the ‘How to use COVIDep’ page of the platform.) Of the 14 epitopes listed in the display, 9 (IEDB IDs 36724, 54507, 54725, 69657, 71663, 2801, 54680, 16156 and 37289) overlap with epitopes against which cytotoxic CD8+ T-cell responses have been observed in peripheral blood mononuclear cells isolated from COVID-19 patients7,8. T-cell responses were also recorded against protein regions overlapping with the epitope with IEDB ID 71663 in a preclinical trial of a DNA vaccine candidate9.

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