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The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting

Overexpression of the RNA methyltransferase METTL6 leads to increased proliferation and promotes cancer. Our cryo-electron microscopy (cryo-EM) and biochemical analyses reveal that METTL6 requires seryl-tRNA synthetase as a cofactor to efficiently generate 3-methyl-cytosine in serine tRNAs.

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Fig. 1: The METTL6–SerRS–tRNASer complex.


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This is a summary of: Throll, P. et al. Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat. Struct. Mol. Biol. (2024).

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The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting. Nat Struct Mol Biol (2024).

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