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Vaccinia virus

Structure of the poxvirus core

Poxviruses range from deadly smallpox to attenuated vaccinia virus used in vaccines and oncolytic vectors. Despite their broad, if antithetical, effects on humankind, the mechanistic details of poxvirus assembly are not known. Here we discuss advances in revealing the structure of the palisade layer which underlies the viral core morphology.

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Fig. 1: Poxviruses: the ultimate viral shapeshifters.

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Acknowledgements

F.C. receives support from the ARC through Discovery Project DP21010338 and DP230101879, and the NHMRC through Ideas Grant 2004582.

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Correspondence to Fasséli Coulibaly.

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Coulibaly, F. Structure of the poxvirus core. Nat Struct Mol Biol 31, 1001–1003 (2024). https://doi.org/10.1038/s41594-024-01331-5

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