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Endosomal trafficking

The commander complex is the Swiss Army knife of endosomal trafficking

The commander complex was recently shown through interactomic screens to be a ubiquitous and conserved protein complex with fundamental biological roles. Two recent reports together revealed the structure of the complete commander assembly and explored its functional implications.

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Fig. 1: Commander structure and its comparison to the retromer membrane coat.
Fig. 2: Comparison of commander models.

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Acknowledgements

N.L. and O.K. are supported by the Max Planck Society.

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Correspondence to Natalya Leneva or Oleksiy Kovtun.

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Leneva, N., Kovtun, O. The commander complex is the Swiss Army knife of endosomal trafficking. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01326-2

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