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HES4 controls redox balance and supports pyrimidine synthesis and tumor growth

NAD(H) redox homeostasis has a fundamental role in cellular metabolism. We screened for potential modulators of NAD(H) using a genome-scale RNA interference (RNAi) approach combined with SoNar, a high-performance sensor that is sensitive to the redox state of NAD(H). Our analysis identified HES4 as a negative regulator of the NADH/NAD+ ratio that influences pyrimidine biosynthesis and exerts a potent oncogenic effect.

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Fig. 1: The role of HES4 in regulating NADH/NAD+ and pyrimidine synthesis.


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This is a summary of: He, J. et al. RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth. Nat. Struct. Mol. Biol. (2024).

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HES4 controls redox balance and supports pyrimidine synthesis and tumor growth. Nat Struct Mol Biol (2024).

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