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Functional epigenomics: chromatin complexity untangled

The development of an epigenetics-focused, CRISPR-based high-content functional genomics screening platform provides insight into chromatin regulation and uncovers a potential strategy to treat an aggressive type of leukemia.

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Fig. 1: CRISPR–ChIP functional genomics platform for analysis of epigenetic pathways regulating H3K4me3 and H3K79me2.


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This work was supported in part by grants from the US National Institutes of Health to O.G. (R35 GM139569 and R01 CA278940) and R.M. (T32 CA009302).

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Correspondence to Or Gozani.

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O.G. is a scientific co-founder and stockholder of EpiCypher, Inc., K36 Therapeutics, Inc. and Alternative Bio, Inc.

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Mack, R., Gozani, O. Functional epigenomics: chromatin complexity untangled. Nat Struct Mol Biol (2023).

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