The development of an epigenetics-focused, CRISPR-based high-content functional genomics screening platform provides insight into chromatin regulation and uncovers a potential strategy to treat an aggressive type of leukemia.
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This work was supported in part by grants from the US National Institutes of Health to O.G. (R35 GM139569 and R01 CA278940) and R.M. (T32 CA009302).
O.G. is a scientific co-founder and stockholder of EpiCypher, Inc., K36 Therapeutics, Inc. and Alternative Bio, Inc.
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Mack, R., Gozani, O. Functional epigenomics: chromatin complexity untangled. Nat Struct Mol Biol (2023). https://doi.org/10.1038/s41594-023-01088-3