Recent studies offer new insight on the mechanisms of IP6-mediated HIV-1 capsid assembly. The immature Gag lattice enables enrichment of IP6 into virions, aiding capsid maturation. Structures of capsid protein (CA) assemblies reveal motifs serving as switches modulating the conformations of CA pentamers/hexamers and affect co-factor accessibility.
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Acknowledgements
Research in the authors’ laboratory is supported in part by National Institutes of Health grants U54AI170791 and R01AI162260.
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Wu, C., Xiong, Y. Enrich and switch: IP6 and maturation of HIV-1 capsid. Nat Struct Mol Biol 30, 239–241 (2023). https://doi.org/10.1038/s41594-023-00940-w
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DOI: https://doi.org/10.1038/s41594-023-00940-w
