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Chromatin and disease

Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer

Nature Structural & Molecular Biology volume 29, pages 1040–1042 (2022)Cite this article

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New research shows that the CoREST complex controls the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data show that this resistance transition is accompanied by a functional retargeting of CoREST on chromatin in coordination with cJUN and SWI/SNF (cBAF).

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Fig. 1: CoREST coordinates the conversion of therapy-sensitive to therapy-resistant states via a functional switch in binding partners in estrogen-deprived T47D cells.

References

  1. Siegel, R. L., Miller, K. D. & Jemal, A. CA Cancer J. Clin. 70, 7–30 (2020).

    Article  PubMed  Google Scholar 

  2. American Cancer Society. Breast Cancer Facts & Figures 2019–2020 (2019).

  3. Patten, D. K. et al. Nat. Med. 24, 1469–1480 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Griffith, O. L. et al. Nat. Commun. 9, 3476 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Garcia-Martinez, L. et al. Nat. Commun. 12, 1786 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yomtoubian, S. et al. Cell Rep. 30, 755–770 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Deblois, G. et al. Cancer Discov. 10, 1312–1329 (2020).

    Article  CAS  PubMed  Google Scholar 

  8. Garcia-Martinez, L. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00856-x (2022).

    Article  PubMed  Google Scholar 

  9. Song, Y. et al. Cell Rep. 30, 2699–2711 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mazumdar, S. et al. PLoS ONE 10, e0121281 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kalin, J. H. et al. Nat. Commun. 9, 53 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Vinckier, N. K. et al. Nat. Commun. 11, 2082 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Vierbuchen, T. et al. Mol. Cell 68, 1067–1082 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lin, R. et al. Cell Biosci. 12, 89 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gao, F. et al. Mol. Cell 75, 891–904 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

B.Y.C. and D.C.H. are supported by US National Institutes of Health grants 5T32GM133351 (B.Y.C), R01 CA228211 (D.C.H.), the Pew-Stewart Scholars for Cancer Research (D.C.H.) and the American Cancer Society Research Scholar Award (D.C.H.)

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Authors and Affiliations

  1. Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA

    Brent Y. Chick & Diana C. Hargreaves

  2. Biological Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA

    Brent Y. Chick

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  1. Brent Y. Chick
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  2. Diana C. Hargreaves
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Correspondence to Diana C. Hargreaves.

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Chick, B.Y., Hargreaves, D.C. Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer. Nat Struct Mol Biol 29, 1040–1042 (2022). https://doi.org/10.1038/s41594-022-00858-9

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