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Lysosome repair

A quick fix for lysosomes

Nature Structural & Molecular Biology volume 29, page 955 (2022)Cite this article

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Lysosomal membrane permeabilization must be resolved to prevent the release of damaging contents. To identify lysosomal repair pathways, Tan and Finkel captured lysosomal surface proteins from cells treated with a lysosome-damaging reagent, and analyzed samples by proximity biotinylation and mass spectrometry. The kinase PI4K2A (which generates the lipid messenger PtdIns4P), as well as the PtdIns4P-binding proteins ORP9 and ORP11, were enriched on damaged lysosomes.

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  1. Nature Structural & Molecular Biology https://www.nature.com/nsmb/

    Katharine H. Wrighton

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  1. Katharine H. Wrighton
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Correspondence to Katharine H. Wrighton.

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Wrighton, K.H. A quick fix for lysosomes. Nat Struct Mol Biol 29, 955 (2022). https://doi.org/10.1038/s41594-022-00847-y

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  • DOI: https://doi.org/10.1038/s41594-022-00847-y

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