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Cell signaling

SHOCing RAF into action

Recent structures of the three-way complex formed by the scaffold protein SHOC2, the small G protein M-RAS and protein phosphatase 1 (PP1) provide a tantalizing insight into the activation of RAF, the oncogenic kinase and downstream effector of RAS that drives cell proliferation and survival.

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Fig. 1: Structural insights into RAF activation.


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Correspondence to Helen R. Mott.

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Mott, H.R., Owen, D. SHOCing RAF into action. Nat Struct Mol Biol 29, 958–960 (2022).

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