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Cell signaling

SHOCing RAF into action

Recent structures of the three-way complex formed by the scaffold protein SHOC2, the small G protein M-RAS and protein phosphatase 1 (PP1) provide a tantalizing insight into the activation of RAF, the oncogenic kinase and downstream effector of RAS that drives cell proliferation and survival.

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Fig. 1: Structural insights into RAF activation.

References

  1. Hauseman, Z. J. et al. Nature https://doi.org/10.1038/s41586-022-05086-1 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kwon, J. J. et al. Nature https://doi.org/10.1038/s41586-022-04928-2 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Liau, N. P. D. et al. Nature https://doi.org/10.1038/s41586-022-04838-3 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Bonsor, D. A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00841-4 (2022).

    Article  PubMed  Google Scholar 

  5. Tran, T. H. et al. Nat. Commun. 12, 1176 (2021).

    Article  CAS  Google Scholar 

  6. Cookis, T. & Mattos, C. Biomolecules 11, 996 (2021).

    Article  CAS  Google Scholar 

  7. Park, E. et al. Nature 575, 545–550 (2019).

    Article  CAS  Google Scholar 

  8. Martinez Fiesco, J. A., Durrant, D. E., Morrison, D. K. & Zhang, P. Nat. Commun. 13, 486 (2022).

    Article  CAS  Google Scholar 

  9. Liau, N. P. D. et al. Nat. Struct. Mol. Biol. 27, 134–141 (2020).

    Article  CAS  Google Scholar 

  10. Kondo, Y. et al. Science 366, 109–115 (2019).

    Article  CAS  Google Scholar 

  11. Bollen, M., Peti, W., Ragusa, M. J. & Beullens, M. Trends Biochem. Sci. 35, 450–458 (2010).

    Article  CAS  Google Scholar 

  12. Peti, W., Nairn, A. C. & Page, R. FEBS J. 280, 596–611 (2013).

    Article  CAS  Google Scholar 

  13. Rodriguez-Viciana, P., Oses-Prieto, J., Burlingame, A., Fried, M. & McCormick, F. Mol. Cell 22, 217–230 (2006).

    Article  CAS  Google Scholar 

  14. Kwon, J. J. & Hahn, W. C. Mol. Cell. Biol. 41, e00627–20 (2021).

    Article  CAS  Google Scholar 

  15. Sulahian, R. et al. Cell Rep. 29, 118–134 (2019).

    Article  CAS  Google Scholar 

  16. Zhou, Y. & Hancock, J. F. Biomolecules 11, 1439 (2021).

    Article  CAS  Google Scholar 

  17. Mysore, V. P. et al. Nat. Struct. Mol. Biol. 28, 847–857 (2021).

    Article  CAS  Google Scholar 

  18. Young, L. C. & Rodriguez-Viciana, P. Cold Spring Harb. Persp. Med. 8, a033621 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Helen R. Mott.

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Mott, H.R., Owen, D. SHOCing RAF into action. Nat Struct Mol Biol 29, 958–960 (2022). https://doi.org/10.1038/s41594-022-00843-2

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