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DNA DAMAGE REPAIR

The key to the FANCD2–FANCI lock

New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for monoubiquitination and recruitment of downstream factors in the Fanconi anemia pathway of DNA damage repair.

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Fig. 1: FANCD2–FANCI padlock.

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Acknowledgements

Studies in the authors’ laboratory are supported by research grants R01 CA168635, PO1 CA92584 and R35 CA241801 from the US National Institutes of Health and by a Team Science Grant from the Gray Foundation under the Basser BRCA Initiative. C.M.R. is the recipient of a postdoctoral fellowship from the American Cancer Society (PF-22-034-01-DMC; https://doi.org/10.53354/pc.gr.153716). P.S. is the holder of the Robert A. Welch Distinguished Chair in Chemistry (AQ-0012) and recipient of a Recruitment of Established Investigators Award from the Cancer Prevention and Research Institute of Texas (RR180029).

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Correspondence to Patrick Sung.

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Rogers, C.M., Sung, P. The key to the FANCD2–FANCI lock. Nat Struct Mol Biol 29, 848–849 (2022). https://doi.org/10.1038/s41594-022-00826-3

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