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The band 3–ankyrin multiprotein complex comes in from the cold

Two new papers describe the successful purification of the partially intact human native red blood cell band 3 multiprotein membrane complexes, providing information that the authors then use to capture the structures and interactions of multiple erythrocyte proteins using high-resolution cryo-EM.

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Fig. 1: A cryo-EM map of the domain organizations of band 3 dimer, protein 4.2 and ankyrin.
Fig. 2: Cryo-EM density map of a B3 ankyrin complexes.


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The author thanks H. Zhou and O. Clarke for their generation of Figs. 1 and 2, respectively, and T. Satchwell for critical reading of this article.

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Correspondence to Ashley M. Toye.

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Toye, A.M. The band 3–ankyrin multiprotein complex comes in from the cold. Nat Struct Mol Biol 29, 621–623 (2022).

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